Background: Neonatal sepsis is a systemic infection occurring in neonatal life and is a major cause of morbidity and mortality in newborns .It accounts for five million newborn deaths
Objectives:- The objective of this study was to assess Prevalence of neonatal sepsis and its determinant factors among neonates admitted in Hiwot-Fana Specialized Referral Hospital, Harar, Ethiopia, 2020
Methods: An institution based cross-sectional study with retrospective document review method was conducted in Hiwot-Fana Specialized Referral Hospital in Harar town. Sample size was calculated by using single population proportion sample formula and the final sample size was 292.The study subject was selected by using systematic random sampling method, and adopted data collection tool was used. Data was analyzed by using SPSS version-20. Descriptive analyses were performed and bivariate analyses were used to find out the association of independent variables.
Result: The overall prevalence of neonatal sepsis in this study was 52.7%..This study found out that PROM of the mother, gestational age of neonates and birth weight of the neonate were significantly associated with neonatal sepsis..
Conclusion: The associated risk factors for neonatal sepsis were identified as PROM of the mother, gestational age of neonates and birth weight of the neonate.
Recommendation:Therefore, preventive efforts should focus on high risk neonates such as neonates born from mothers who have PROM, neonate with low birth weight and neonates born prematurely. Thus, a careful monitoring and follow up as well as rigorous treatment are needed.
- Simonsen KA, Anderson-Berry AL, Delair SF, Davies HD. Early-onset neonatal sepsis. Clinical microbiology reviews. 2014;27(1):21-47.
- Cizmeci MN, Kara S, Kanburoglu MK, Simavli S, Duvan CI, Tatli MM. Detection of cord blood hepcidin levels as a biomarker for early-onset neonatal sepsis. Medical hypotheses. 2014;82(3):310-2.
- Adhikari NK, Fowler RA, Bhagwanjee S, Rubenfeld GD. Critical care and the global burden of critical illness in adults. The Lancet. 2010;376(9749):1339-46.
- Berardi A, Cattelani C, Creti R, Berner R, Pietrangiolillo Z, Immaculada M, et al. Group B streptococcal infections in the newborn infant and the potential value of maternal vaccination. Expert Rev Anti Infect Ther. [Internet] 2015; 13(11) .
- UNICEF (2014). Committing to Child Survival: A Promise Renewed pp.1-102. https://data.unicef.org/wp-content/uploads/2015/12/APR-2014-17Oct14-web_194.pdf
- Central statistical Agency (CSA) and Ethiopian Demographic health survey Addis Ababa Ethiopia, 2016.
- Alkema L, New JR, Pedersen J, You D. Child mortality estimation 2013: an overview ofupdates in estimation methods by the United Nations Inter-agency Group for Child Mortality Estimation. PloS one. 2014;9(7):e101112.
- Moges F, Eshetie S, Yeshitela B, Abate E. Bacterial etiologic agents causing neonatal sepsis and associated risk factors in Gondar, Northwest Ethiopia. BMC pediatrics. 2017;17(1):137.
- Gebremedhin D, Berhe H, Gebrekirstos K. Risk factors for neonatal sepsis in public hospitals of Mekelle City, North Ethiopia, 2015: unmatched case control study. PloS one. 2016;11(5):e0154798.
- Tewabe T, Mohammed S, Tilahun Y, Melaku B, Fenta M, Dagnaw T, et al. Clinical outcome and risk factors of neonatal sepsis among neonates in Felege Hiwot referral Hospital, Bahir Dar, Amhara Regional State, North West Ethiopia 2016: a retrospective chart review. BMC research notes. 2017;10(1):265.
- Leal YA, Álvarez-Nemegyei J, Velázquez JR, Rosado-Quiab U, Diego-Rodríguez N, Paz- Baeza E, et al. Risk factors and prognosis for neonatal sepsis in southeastern Mexico: analysis of a four-year historic cohort follow-up. BMC pregnancy and childbirth. 2012;12(1):48.
- Wang ME, Patel AB, Hansen NI, Arlington L, Prakash A, Hibberd PL. Risk factors for possible serious bacterial infection in a rural cohort of young infants in central India. BMC public health. 2016;16(1):1097.
- Santhanam S, Arun S, Rebekah G, Ponmudi NJ, Chandran J, Jose R, et al. Perinatal Risk Factors for Neonatal Early-onset Group B Streptococcal Sepsis after Initiation of Risk-based Maternal Intrapartum Antibiotic Prophylaxis—A Case Control Study. Journal of tropical pediatrics. 2017;64(4):312-6.
- John B DM, Mathias L, Elizabeth N:. Risk factors and practices contributing to newborn sepsis in a rural district of Eastern Uganda, August 2013: a cross sectional study . BMC research notes 2015, 8:339.
- Aytenew G, Mihret A, Endashaw F, Tomas Y. Prevalence of Neonatal Sepsis and Associated Factors among Neonates in Neonatal Intensive Care Unit at Selected Governmental Hospitals in Shashemene Town, Oromia Regional State, Ethiopia, 2017; Hindawi International Journal of Pediatrics Volume 2018, Article ID 7801272, 7
- M. Rakhsha, L. Pourali, S. Ayati , H.Boskabadi, K.Kazemi, M.TS.“Effective Maternal and Neonatal Factors Associated with the Prognosis of Preterm Infants in Iran Patient SafQualImprov,” 2016.
- Woldu MA, Guta MB, Lenjisa JL, Tegegne GT , Tesafye G , Dinsa H.Assessment of the Incidence of Neonatal Sepsis, its Risk Factors, Antimicrobials Use and Clinical Outcomes in Bishoftu General Hospital, Neonatal Intensive Care Unit, Debrezeit–Ethiopia. Pediat Therapeut. 2014;4(3):214
- Getabelew A, Aman M, Fantaye E, Yeheyis T. Prevalence of neonatal sepsis and associated factors among neonates in neonatal intensive care unit at selected governmental hospitals in Shashemene Town, Oromia Regional State, Ethiopia, 2017. Int J Pediatr. 2018.
- Evelyn M, Andreas C, Fanny L, Seraphin N, Jean B, Hyppolyte S,et al. “Neonatalmortality in a referral hospital in Cameroon over a seven yearperiod: Trends, associated factors and causes,” African HealthSciences, vol. 14, no. 4, pp. 985–992, 2014.
- Verma P, Berwal PK, Nagaraj N, Swami S, Jivaji P, Narayan S. Neonatal sepsis: epidemiology, clinical spectrum, recent antimicrobial agents and their antibiotic susceptibility pattern. Int J Contemp Pediatrics. 2017;2(3):176–80.
- Le Geyt J, Hauck S. G272 epidemiological trends of neonatal sepsis in a county referral hospital in Central Kenya; 2016
- Jabiri A, Wella HL, Semiono A, Saria A, Protas J. Prevalence and factors associated with neonatal sepsis among neonates in Temeke and Mwananyamala Hospitals in Dar es Salaam, Tanzania. Tanzania J Health Res. 2016;18(4).
- E. M. R. Shehab El-Din, M. M. A. El-Sokkary,M. R. Bassiouny, and R.Hassan, “Epidemiology of neonatal sepsis and implicated pathogens:AStudy fromEgypt,” BioMed Research International, vol. 2015, Article ID 509484, 2015.
- D. Shitaye, D. Asrat, Y. Woldeamanuel, and B. Worku, “Risk factors and etiology of neonatal sepsis in Tikur Anbessa University Hospital, Ethiopia.,” Ethiopian Medical Journal, vol. 48, no. 1, pp. 11–21, 2010.
- Dal-Bó K, Silva RM, Sakae TM. Nosocomial infections in a neonatal intensive care unit in South Brazil. Rev Bras Ter Intensiva. 2012;24(4):381–5.
- Gebremedhin D, Berhe H, Gebrekirstos K. Risk factors for neonatal sepsis in public hospitals of Mekelle City, North Ethiopia, 2015: unmatched case control study. PLoSONE. 2016. https://doi.org/10.1371/journal.pone.0154798
- René OP, Juan C L, Moisés Q, Miguel ÁV, Elba PA, Edith AB. Early neonatal sepsis, incidence and associated riskfactors in a public hospital in western Mexico. Revistachilena de infectologia: organooficial de la SociedadChilena de Infectologia. 2015;32(4):387–392.
Copyright (c) 2021 INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT (IJHSRD)

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Copyright Rights & Permissions Guide
Reproducing Published Material from other Publishers
It is absolutely essential that authors obtain permission to reproduce any published material (figures, schemes, tables or any extract of a text) which does not fall into the public domain, or for which they do not hold the copyright. Permission should be requested by the authors from the copyright holder (usually the Publisher, please refer to the imprint of the individual publications to identify the copyright holder).
Permission is required for:
- Your own works published by other Publishers and for which you did not retain copyright.
- Substantial extracts from anyones’ works or a series of works.
- Use of Tables, Graphs, Charts, Schemes and Artworks if they are unaltered or slightly modified.
- Photographs for which you do not hold copyright.
Permission is not required for:
- Reconstruction of your own table with data already published elsewhere. Please notice that in this case you must cite the source of the data in the form of either “Data from…” or “Adapted from…”.
- Reasonably short quotes are considered fair use and therefore do not require permission.
- Graphs, Charts, Schemes and Artworks that are completely redrawn by the authors and significantly changed beyond recognition do not require permission.
Obtaining Permission
In order to avoid unnecessary delays in the publication process, you should start obtaining permissions as early as possible. If in any doubt about the copyright, apply for permission. JNH cannot publish material from other publications without permission.
The copyright holder may give you instructions on the form of acknowledgement to be followed; otherwise follow the style: “Reproduced with permission from [author], [book/journal title]; published by [publisher], [year].’ at the end of the caption of the Table, Figure or Scheme.
Every mansucript should be accompanied by "Copyright Transfer Agreement" prior to the article publication
Similar Articles
- La Djabo Buton, Fitri Rachmillah Fadmi, Is It Truly Household Income Affect Underweightin Children Under Five Years Old ? Evidence From Indonesia: Underweightin Children , INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT (IJHSRD): Vol. 5 No. 1 (2023): INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT
- Ritu Chauhan, Anuradha Verma, Tushar Singhal, Anshika Garg, Babita Kumar, Dayanidhi Pandey, Design And Evaluation Of Teneligliptin Tablet: Teneligliptin Tablet , INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT (IJHSRD): Vol. 5 No. 1 (2023): INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT
- Tasnim Tasnim, Sunarsih Sunarsih, Timbul Supodo, THE PREVENTIVE MODEL FOR CHRONIC KIDNEY DISEASE IN COASTAL AREA ABELI HEALTH CENTRE IN KENDARI CITY: Preventive model of CKD , INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT (IJHSRD): Vol. 5 No. 2 (2023): INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT
- Tasnim Tasnim, Sugireng Sugireng, Imran Imran, Nur Illiyyin Akib, Early Detection Patterns Of Chronic Kidney Disease Based On Differences In Individual Health Status In Kendari City: Chronic Kidney Disease , INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT (IJHSRD): Vol. 5 No. 2 (2023): INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT
- Armayani Armayani, Faridah Mohd Said, Nisha Nambiar , Ratna Umi Nurlila, The Effect Of Brain Gym For Kognitif Function In Elderly Kendari City Healtyh Center: Brain Gym For Kognitif Function , INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT (IJHSRD): Vol. 6 No. 1 (2024): INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT
- Witri Pratiwi, Yogi Puji Rachmawan, Profile Of Congenital Heart Disease (CHD) Patients In Cirebon, Indonesia: Maternal Passive Smoking Risk : Maternal Passive Smoking Risk , INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT (IJHSRD): Vol. 6 No. 1 (2024): INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT
- Fatmawati Fatmawati, Petrus, Jusuf Kristianto, Ellyani Abadi, Tenri Zulfa Ayu Dwi Putri, TRENDS IN MATERNAL EMPLOYMENT AND EDUCATION STATUS OF STUNTING AND NON-STUNTING TODDLERS IN COASTAL AREAS OF KENDARI CITY: STUNTING , INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT (IJHSRD): Vol. 6 No. 2 (2024): INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT
- Tasnim Tasnim, La Ode Saafi, Sanihu Munir, Kadek Ayu Karuniawati, Fitri Fitri, Nuzul Wahyuning Tias, Ririn Putri Handayani, Indriani Indriani, Eka Putri Sari, Wa Ode Fitra Saripati, THE RELATIONSHIP BETWEEN PERCEPTION OF SUSCEPTIBILITY AND SERIOUSNESS OF DISEASE WITH INDIVIDUALS’ ADEQUACY WATER INTAKE IN SOUTHEAST SULAWESI: Water intake and perception , INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT (IJHSRD): Vol. 6 No. 2 (2024): INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT
- Haris Muzakir, Khaerunisa Putri Lorenzo, THE RELATIONSHIP BETWEEN THE OCCUPATIONAL FACTORS AND HEARING IMPAIRMENT IN PT. BINDER INDONESIA WORKERS: OCCUPATIONAL FACTORS AND HEARING IMPAIRMENT , INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT (IJHSRD): Vol. 7 No. 1 (2025): INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT
- Laode Saltar, Adi Risaldi, Achmad Kadarman, Heltty, DETERMINANTS OF HEALTH SERVICE UTILIZATION IN LOW-INCOME FAMILIES IN THE COASTAL REGION OF MAGINTI ISLAND, WEST MUNA REGENCY: A CROSS-SECTIONAL STUDY: HEALTH SERVICE UTILIZATION IN LOW-INCOME FAMILIES , INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT (IJHSRD): Vol. 7 No. 1 (2025): INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT
You may also start an advanced similarity search for this article.
Most read articles by the same author(s)
- Arif Hussen Jamie, Elias Sertse Gebremedhin, KNOWLEDGE AND ATTITUDE TOWARDS EXPRESSED BREAST MILK AMONG WORKING MOTHERS IN HARARI REGIONAL STATE, ETHIOPIA, 2021: EXPRESSED BREAST MILK , INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT (IJHSRD): Vol. 4 No. 1 (2022): INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT





