Design And Evaluation Of Teneligliptin Tablet

Teneligliptin Tablet
Ritu Chauhan 1 India , Anuradha Verma 1 India , Tushar Singhal 1 India , Anshika Garg 1 India , Babita Kumar 1 India , Dayanidhi Pandey 2 India
1 Sanskar College Of pharmacy and Research
2 Himachal Pradesh, India
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Published 2023-06-27
Vol. 5 No. 1 (2023) PAGES 89-100
DOI 10.36566/ijhsrd/Vol5.Iss1/153
Views / Downloads 846 1134

Background : Excessive workload, stress, and, genetic disorders are the main reason for the increasing prevalence of Type II diabetes in India. Teneligliptin, is a potent Dipeptidyl peptidase (DPP-4) inhibitor that exerts its action in Type II diabetes mellitus. Teneligliptin mainly acts by increasing insulin levels and decreasing glucagon levels in the circulation in a glucose-dependent manner. It offers sufficient glycemic control in a period of 12 weeks ad is also tolerable by renal-impaired patients.

Methods: Six formulations of teneligliptin tablets were prepared by using different ratios of MCC, maize starch, HPMC, HPC, aerosol, and magnesium stearate. The prepared tablets were evaluated in terms of friability, hardness, disintegration, and dissolution rate profile

Results: Out of all six formulations, F4 reflects better tablet characteristics as compared to the rest five formulations

Conclusions: F4 turns out to be the best formulation of the present study and can be used for commercial production.

Design And Evaluation Of Teneligliptin Tablet: Teneligliptin Tablet. (2023). INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT (IJHSRD), 5(1), 89-100. https://doi.org/10.36566/ijhsrd/Vol5.Iss1/153
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Keywords
Teneligliptin Diabetes mellitus glycemic control disintegration formulation insulin

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